In Depth Variant Analysis:  c.197C>T (p.Pro66Leu)
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c.197C>T
p.Pro66Leu (Legacy AA No. 48)
Variant Type:  
Point
Domain:  
Apple 1
Codon Change: 
C>T
Variant Effect: 
Missense
No. of Patients Reported: 
0
Phenotype: 
None
Allele Count *: 
18
Allele Number *: 
282848
Allele Frequency *: 
0.000064
Variant Comments & Reference:
Polymorphism. Cargill et al 1999Residue Information:
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Substitution Analysis:
Structural Implications:
Pro66 is an exposed residue  (surface accessibility value = 8 ).
Pro66 is in a random coil area of the FXI structure.
The DSSP assignment for this residue is ... T.
Pro66 is in a random coil area of the FXI structure.
The DSSP assignment for this residue is ... T.
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